Aim Hepatocellular carcinoma (HCC) patients with sarcopenia have a poor survival, but there are no predictive markers for survival relating to muscle mass and liver function. Therefore, we investigated whether the ratio between estimated glomerular filtration rates of serum creatinine (Scre) and serum cystatin C (Scys)(eGFRcre/eGFRcys) can be used as a predictive marker of survival in HCC patients. Methods First, the correlation between Scre/Scys ratio and muscle mass was examined in 50 patients with chronic liver disease …

The diagnostic performance of supersonic shear imaging (SSI) in comparison with those of transient elastography (TE) and acoustic radiation force impulse imaging (ARFI) for staging fibrosis in nonalcoholic fatty liver disease (NAFLD) patients has not been fully assessed, especially in Asian populations with relatively lean NAFLD compared to white populations. Thus, we focused on comparing the diagnostic performances of TE, ARFI, and SSI for staging fibrosis in a head-to-head manner, and identifying the clinical, anthropometric …

The excessive body fat, one of the results of obesity, brings with it comorbidities such as lipid changes, insulin resistance, diabetes mellitus type 2 and non-alcoholic fatty liver disease. In this controlled and randomized pilot study, as a non-pharmacological and non-invasive strategy, we consider two groups during 8 weeks: the use of moderate intensity physical exercise and nutritional education, as control group (n= 10) and moderate intensity physical exercise, nutritional education and phototherapy (n= 10), as phototherapy group. The used …

Aim: To clarify the impact of visceral fat on chronic liver diseases such as non‐alcoholic fatty liver disease (NAFLD) and hepatitis C, we investigated the effects of lifestyle modifications on the amount of visceral fat, liver biochemistry and serum ferritin levels in patients with liver disease. Methods: Eighty‐two patients (NAFLD, n= 37; hepatitis C, n= 45) were advised to adopt lifestyle modifications, including dietary changes and exercise, and these were maintained for 6 months. Bodyweight, percentage of body fat, visceral fat area (VFA) and …

Objective To identify nonalcoholic steatohepatitis (NASH) and liver stiffness in Mexican subjects with different body mass index (BMI). Methods A cross-sectional study was conducted in 505 adults. Risk for NASH was defined as the presence of one or more of the following biochemical and metabolic parameters (BMPs): fasting glucose≥ 100 mg/dl, triglycerides (TG)≥ 150 mg/dl, homeostatic model assessment of insulin resistance (HOMA-IR)≥ 2.5, aspartate aminotransferase (AST)> 54 IU/L and alanine aminotransferase (ALT)> …

Background & aims Serum albumin exists in oxidized and reduced forms. Although oxidation of albumin affects some functions of albumin, the involvement of oxidized albumin in disease progression and water retention in patients with chronic liver disease remains unclear. The aim of this study was to determine whether there is an association between oxidized albumin and water retention in patients with chronic liver disease. Methods Seventy-nine patients with chronic viral liver diseases and 31 cirrhotic patients with …

Background: Physical inactivity is a major risk factor for nonalcoholic fatty liver disease (NAFLD). Exercise-based prevention interventions for improving cardiorespiratory fitness are a recommended complementary treatment for NAFLD. Achievement of minimally effective physical activity to improve cardiorespiratory fitness among patients typically involves high personal and financial expenses in face-to-face settings. We designed an eHealth approach for patients with NAFLD to improve the cardiorespiratory fitness and …

Aim Recently, the short‐term efficacy of the vasopressin V2 receptor antagonist tolvaptan for the treatment of ascites in cirrhosis was reported. However, the long‐term effects remain unknown. Here, we report the clinical features of decompensated cirrhosis treated using long‐term tolvaptan therapy, and evaluate its safety and efficacy. Methods Fifty‐five cirrhotic patients hospitalized due to ascites, despite receiving appropriate diuretic treatment, were treated with tolvaptan. We excluded 35 patients due to liver transplant (20.0%), death …

Nonalcoholic fatty liver disease (NAFLD) has been associated with relative skeletal muscle mass in several cross‐sectional studies. We explored the effects of relative skeletal muscle mass and changes in relative muscle mass over time on the development of incident NAFLD or the resolution of baseline NAFLD in a large, longitudinal, population‐based 7‐year cohort study. We included 12,624 subjects without baseline NAFLD and 2943 subjects with baseline NAFLD who underwent health check‐up examinations. A total of 10,534 subjects …

Background/Aim: This study aimed to assess the clinical significance of measuring the arm skeletal muscle mass in patients with cirrhosis. Patients and Methods: Using body composition data measured with the bioimpedance analysis (BIA) method, the skeletal muscle mass index (SMI) values of the arm (arm skeletal muscle mass/height 2) and leg (leg skeletal mass muscle/height 2) were calculated for 353 patients with cirrhosis, and the relationships of these indices to their prognosis were assessed. In addition, overhydration of …