Background/Aim: A bioimpedance analysis (BIA) can indicate an overhydrated state as the extracellular water/total body water (ECW/TBW) value. This study aimed to assess the clinical significance of this value in patients with chronic liver diseases (CLDs). Patients and Methods: A total of 552 CLD patients who received a liver biopsy and underwent anthropometric assessment and BIA-based body composition analysis were enrolled. The association of the ECW/TBW value with the liver fibrosis and nutritional status was assessed …

Results Compared with the placebo, supplementing phospholipid curcumin resulted in significant decreases in serum including 3-methyl-2-oxovaleric acid, 3-hydroxyisobutyrate, kynurenine, succinate, citrate, α-ketoglutarate, methylamine, trimethylamine, hippurate, indoxyl sulfate, chenodeoxycholic acid, taurocholic acid, and lithocholic acid. This profile of metabolic biomarkers could distinguish effectively NAFLD subjects who were treated with curcumin and placebo groups, achieving value of 0.99 for an area under receiver operating …

Abstract Background and Aim Patients with cirrhosis usually experience muscle cramps of varying severity. Although diuretics have been reported to cause muscle cramps, clinical evidence is limited. Also, it has been pointed out that the use of diuretics is associated with the progression of sarcopenia in patients with cirrhosis. We conducted a questionnaire survey to clarify the effects of diuretics and skeletal muscle loss on muscle cramps. Methods Overall, we enrolled 152 adults with cirrhosis in this study. Cramp questionnaires were …

Aim Sarcopenia is common in patients with advanced fibrosis or cirrhosis. We investigated the correlation between sarcopenia and other clinical variables, in particular, significant liver fibrosis in patients with chronic liver diseases (CLDs).

Methods This study was nested within the Houston Barrett's Esophagus study, conducted in Michael E DeBakey Veterans Affairs Medical Center and previously described in detail (7). We included adults who had undergone BIA as part of the study, had abdominal imaging (CT, MRI, or ultrasound) within 6 months of enrollment, and no reported viral hepatitis or excessive alcohol use (> 7 and> 14 beverages/week respectively in women and men). NAFLD was determined based on imaging detected hepatic steatosis.

Abstract Background and Aim Although low skeletal muscle mass (LSMM) is known to increase the risk of non‐alcoholic fatty liver disease (NAFLD), limited reports have described the relationship between LSMM and advanced fibrosis. Here, we investigated the association between LSMM and advanced liver fibrosis in NAFLD patients. Methods Fatty liver was diagnosed using ultrasound, and appendicular skeletal muscle mass (ASM) was measured using bioelectrical impedance analysis. LSMM was defined in two ways …

Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Insulin resistance, oxidative stress, and obesity are major contributors to NAFLD pathogenesis. The effects of garlic powder supplementation on these risk factors in patients with NAFLD was investigated. Methods In this 12-wk, randomized controlled clinical trial, ninety patients with NAFLD were randomly assigned to two groups. The treatment group received four tablets of garlic (each coated tablet contained 400 mg garlic powder) …

Background The enhancement of oxidative stress in non-alcoholic fatty liver disease (NAFLD) patients may cause mutation in DNA by deamination of cytosine to 5-hydroxyuracil or uracil. This study aimed to discover the effects of curcumin on NAFLD progress, DNA damage caused by oxidative stress, and promoter methylation of mismatch repair enzymes. Material and methods in this study, 54 NAFLD patients were randomly devided into two groups, according to a double blind parallel design either phytosomal curcumin (250 …

Objetivo: Para investigar el papel de la dieta hipocalórica rica en proteínas, se realizó un estudio clínico prospectivo en pacientes con HPGNA. Métodos de investigación y procedimientos: Se analizaron los datos antes y después de la intervención en 48 pacientes con HPGNA estable, sometidos a una dieta hipocalórica y rica en proteínas durante 75 días. Las variables incluían medidas antropométricas (índice de masa corporal (IMC) y circunfe-rencia de la cintura (CC)), análisis de bioimpedancia corporal completa y segmentaria y …

Ninety seven patients with chronic hepatitis C (CHC) and 72 with non-alcoholic fatty liver disease (NAFLD) were enrolled. Increased visceral fat area (VFA) was associated with high values of HbA1c. The variables associated with a high risk of new-onset diabetes had a VFA> 101 cm 2 in CHC, but not in NAFLD.