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Dihydromyricetin stimulates irisin secretion partially via the PGC-1α pathway

Body Composition Assessment
Author
Zhou Q et al.
Used Parameters : PBF

Publication Year : 2015

Country : China

Journal : Molecular and Cellular Endocrinology

Irisin, derived from FNDC5, is an exercise-induced myokine that can stimulate the 'browning'of white adipose tissue, which is regulated by peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α). Dihydromyricetin (DHM), a natural flavonoid, exerts its activities through PGC-1α activation. Here, we explored whether DHM could mimic the effects of exercise on irisin secretion. DHM administration increased circulating irisin in rats and humans. Notably, the serum irisin level had a greater correlation to the level of …
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