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Dual impact of tolvaptan on intracellular and extracellular water in chronic kidney disease patients with fluid retention

Nephrology
Author
T Masuda et al.
Used Parameters : TBW, ECW, ICW, ECW/TBW
Publication Year : 2016
Country : Japan
Journal : Internal Medicine
Objective Tolvaptan, an oral selective V2-receptor antagonist, is a water diuretic that ameliorates fluid retention with a lower risk of a worsening renal function than conventional loop diuretics. Although loop diuretics predominantly decrease extracellular water (ECW) compared with intracellular water (ICW), the effect of tolvaptan on fluid distribution remains unclear. We therefore examined how tolvaptan changes ICW and ECW in accordance with the renal function. Methods Six advanced chronic kidney disease patients (stage 4 or 5) with …
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