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Sodium-glucose cotransporter 2 inhibition with dapagliflozin ameliorates extracellular volume expansion in diabetic kidney dise

Endocrinology
Nephrology
Author
T Masuda et al.
Used Parameters : TBW, ICE, ECW, ECW/TBW, Segmental ECW/TBW
Publication Year : 2017
Country : Japan
Journal : OJ Diabetes & Obesity Management
Background: Sodium-glucose cotransporter (SGLT) 2 inhibitors, a new class of antidiabetic drugs, have diuretic properties, but their effects on urinary Na excretion and the fluid status have not been fully evaluated. Methods: Diabetic kidney disease (DKD) patients with fluid retention were enrolled in this study. The SGLT2 inhibitor dapagliflozin was administered in addition to conventional treatment. Blood and 24-h urine samples were collected before dapagliflozin dosing on day 0 and afterwards on days 2 and 7. The fluid volume was …
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