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Interactions among the variants of insulin-related genes and nutrients increase the risk of type 2 diabetes

Endocrinology
Author
KW Hong et al.
Used Parameters : BFM
Publication Year : 2018
Country : Korea
Journal : Nutrition Research
Asians easily develops type 2 diabetes (T2DM) since they have insufficient glucose-stimulated insulin secretion (GSIS) in insulin resistant states. Since this may be associated with genetic background, the hypothesis of this study was that inter-genetic and gene-nutrient interactions may explain the low insulin secretory capacity of Asians. Accordingly, we identified the best gene-gene and gene-nutrient interactions using generalized multifactor dimensionality reduction (GMDR) in a large Korean cohort (n= 8,842). Initially, we …
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