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Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars

Nutrition
Author
Luukkonen and Associates
Used Parameters : FFM
Publication Year : 2018
Country : Finland
Journal : Diabetes Care
OBJECTIVE Nonalcoholic fatty liver disease (ie, increased intrahepatic triglyceride [IHTG] content), predisposes to type 2 diabetes and cardiovascular disease. Adipose tissue lipolysis and hepatic de novo lipogenesis (DNL) are the main pathways contributing to IHTG. We hypothesized that dietary macronutrient composition influences the pathways, mediators, and magnitude of weight gain-induced changes in IHTG. RESEARCH DESIGN AND METHODS We overfed 38 overweight subjects (age 48±2 years, BMI 31±1 kg/m 2, liver …
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