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Different effects on fluid distribution between tolvaptan and furosemide in a liver cirrhosis patient with chronic kidney disea

Nephrology
Hepatology
Author
I Nagayama et al.
Used Parameters : TBW, ICW, ECW, ECW/TBW
Publication Year : 2019
Country : Japan
Journal : Internal Medicine
A 73-year-old man with liver cirrhosis and advanced chronic kidney disease was admitted to our hospital due to bilateral lower leg edema and appetite loss. Furosemide to treat fluid retention markedly decreased extracellular water compared with intracellular water, but the addition of tolvaptan equally decreased both with a greater diuretic response than furosemide alone. Furthermore, tolvaptan administration increased the plasma colloid osmotic pressure, which might facilitate the shift of fluid from the extravascular space to the …
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