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Metabolic acidosis augments exercise pressor responses in chronic kidney disease

Nephrology
Author
Sprick et al.
Used Parameters : PBF
Publication Year : 2019
Country : USA
Journal : American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Chronic kidney disease (CKD) patients experience augmented blood pressure (BP) reactivity during exercise that is associated with an increased risk of cardiovascular mortality. Exaggerated exercise pressor responses in CKD are in part mediated by augmented sympathetic nerve activation due to heightened muscle mechanoreflex. One mechanism that may lead to sensitization of the muscle mechanoreflex in CKD is metabolic acidosis. We hypothesized that CKD patients with low serum [bicarbonate] would exhibit …
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