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Recapitulation of the Association of the Val66Met Polymorphism of BDNF Gene With BMI in Koreans

Body Composition Assessment
Author
Kyung-Won Hong
Used Parameters : PBF

Publication Year : 2012

Country : Korea

Journal : Obesity

Recent evidence suggests that brain‐derived neurotrophic factor (BDNF) regulates food intake and the control of body weight. A common polymorphism in human BDNF, Val66Met (single‐nucleotide polymorphism database (dbSNP) no. rs6265), impairs intracellular trafficking, resulting in the reduced secretion of BDNF. Several European studies have indicated that Val66Met is associated with BMI. In this study, we examined the association of the Val66Met polymorphism with BMI in Koreans (n= 20,270) from three independent …
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