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Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women

Endocrinology
Author
Hyun-Seok Jin, et al.
Used Parameters : BMI, PBF,
WHR
Publication Year : 2013
Country : Korea
Journal : Molecular Genetics and Metabolism
Background Emerging evidence has revealed a close relationship between obesity and osteoporosis. It was reported recently that conditional knockout of the Spry1 gene in mice adipocytes causes an increase in body fat and a decrease in bone mass, and that these phenotypes are rescued by Spry1 overexpression in adipose tissue. In this study, we investigated whether genetic variation in the human SPRY1 gene is associated with obesity-related phenotypes and/or osteoporosis in humans. Methods We performed a candidate …
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