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A link between FTO, ghrelin, and impaired brain food-cue responsivity

Nutrition
Author
Efthimia Karra et al.
Used Parameters : BFM
Publication Year : 2013
Country : UK
Journal : Journal of Clinical Investigation
Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with human obesity and obesity-prone behaviors, including increased food intake and a preference for energy-dense foods. FTO demethylates N6-methyladenosine, a potential regulatory RNA modification, but the mechanisms by which FTO predisposes humans to obesity remain unclear. In adiposity-matched, normal-weight humans, we showed that subjects homozygous for the FTO “obesity-risk” rs9939609 A allele have dysregulated …
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