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Comprehensive evaluation of the neuropeptide-Y gene variants in the risk of obesity: a case–control study and meta-analysis

Pediatrics
Endocrinology
Author
Zain SM et al.
Used Parameters : PBF
Publication Year : 2015
Country : Malaysia
Journal : Pharmacogenet Genomics
Background Orexigenic actions mediated by neuropeptide-Y (NPY) promote body weight regulation. Genetic variations in the NPY gene could therefore influence susceptibility to obesity, but results have been conflicting. We have carried out, for the first time, a case–control study to examine the effect of NPY rs16147 and rs5574 variants with the risk of obesity in Asians and also a meta-analysis to summarize the effect of these variants including that of the widely studied rs16139. Materials and methods Genotypes and …
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