Background: Thyroid hormones are important regulators of glucose homeostasis. However, the association between thyroid hormones within the reference range and type 2 diabetes mellitus (T2DM) remains unclear. The aim of this study was to clarify the incidence of T2DM according to the baseline levels and changes of thyrotropin (TSH) and thyroid hormones (free thyroxine and triiodothyronine) in euthyroid subjects. Methods: Among the participants who consecutively underwent thyroid function tests between 2006 and 2012 through a …

The beneficial effects of a strength exercise program and a combined exercise program of strength training plus walking were examined in overweight with chronic back pain patients. The participants were randomly placed in the strength exercise group (SEG, n= 15), combined exercise group (CEG, n= 15), and control group (CG, n= 6). All subjects performed exercise twice per week, 50 min per session with a professional instructors for 12 weeks. In order to evaluate exercise intervention effects, lumbar function was measured by back …

Background physical performance is a key factor that determines how older people cope with daily tasks and maintain independency. There is strong evidence suggesting that physical activity (PA) is important in maintaining physical performance in old age. However, most studies have been done using self-reported PA. Our aim was to explore the association between objectively measured PA and physical performance in old age. Methods we studied 695 participants (mean age 70.7 years, SD 2.7) from the Helsinki Birth Cohort Study …

The purpose of this study was to compare the effects of two similar high-intensity intermittent exercises (HIIE) but different volume 1.25 km (HIIE1. 25) and 2.5 km (HIIE2. 5) on inflammatory and BDNF responses. Ten physically active male subjects (age 25.22±1.74 years, body mass 78.98±7.31 kg, height 1.78±0.06 m, VO2peak 59.94±9.38 ml• kg• min-1) performed an incremental treadmill exercise test and randomly completed two sessions of HIIE on a treadmill (1: 1 min at vVO2max with passive recovery). Blood samples were …

Aim The present study evaluates autonomic and somatic nerve function in different stages of glucose tolerance and its correlation with different cardio-metabolic parameters. Material and methods Four hundred seventy-eight subjects, mean age 49.3±13.7 years and mean BMI 31.0±6.2 kg/m2, divided according to glucose tolerance: 130 with normal glucose tolerance (NGT), 227 with prediabetes (125 with impaired fasting glucose (IFG) and 102 with isolated impaired glucose tolerance (iIGT)), and 121 with newly-diagnosed T2D (NDT2D) …

Bioelectrical impedancemetry (BIA) has been used to evaluate hematocrit and red cell aggregability in vitro but whole body impedance measurements are also correlated to some hemorheologic factors, suggesting a relationship between viscosity factors and electric properties of blood. We repeatedly reported correlations with whole body BIA and hematocrit, whole blood viscosity and plasma viscosity, red cell rigidity and RBC aggregation. The SBIA Inbody 770 modelizes body as 5 cylinders and measures impedance …

Background SARC-F is a 5-item, self-administered questionnaire developed to screen sarcopenia. To date, no Japanese version of the SARC-F has been developed. Aims To create a Japanese version of the SARC-F (SARC-FJ), a questionnaire for diabetic patients, and to investigate its reliability and validity. Methods This was a cross-sectional study. A Japanese translation of the SARC-F was created and revised, and the authors of the original version of the SARC-F verified the back-translation. The questionnaire was tested in diabetic …

Hyperinsulinaemia is the earliest subclinical metabolic abnormality, which precedes insulin resistance in obese children. An investigation was conducted on the potential predictors of fasting insulin and insulin resistance among overweight/obese adolescents in a developing Asian country. A total of 173 overweight/obese (BMI> 85 th percentile) multi-ethnic Malaysian adolescents aged 13 were recruited from 23 randomly selected schools in this cross-sectional study. Waist circumference (WC), body fat percentage (BF%), physical …

Sodium glucose cotransporter 2 inhibitors are unique antihyperglycemic agents that cause osmotic diuresis and calorie loss to urine. We previously reported that administration of tofogliflozin, a sodium glucose cotransporter 2 inhibitor, for 8 weeks decreased fat-free mass without affecting fat mass. We thus investigated the impact of tofogliflozin on metabolic parameters and body composition for 48 weeks in Japanese patients with type 2 diabetes mellitus. This single-arm open-label study enrolled 20 patients. Patients received …