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Impact of serum albumin levels on the body fluid response to tolvaptan in chronic kidney disease patients

Nephrology
Author
Masuda et al.
Used Parameters : TBW, ICW, ECW, ECW/TBW
Publication Year : 2019
Country : Japan
Journal : International Urology and Nephrology
Purpose Tolvaptan exerts an aquaretic effect by blocking vasopressin V2 receptor. Although tolvaptan ameliorates body fluid retention even in patients with chronic kidney disease (CKD), predictors of body fluid reduction induced by tolvaptan remain unclear. We, therefore, examined the clinical parameters associated with the effect of tolvaptan on fluid volume in CKD patients. Methods Twelve CKD patients (stage 3–5) with fluid retention were treated with tolvaptan in addition to conventional diuretic treatment. Patients were divided into low …
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