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A pilot study of the effect of curcumin on epigenetic changes and DNA damage among patients with non-alcoholic fatty liver dise

Hepatology
Author
Hariri et al.
Used Parameters : WHR, PBF, FFM
Publication Year : 2020
Country : Iran
Journal : Complementary Therapies in Medicine
Background The enhancement of oxidative stress in non-alcoholic fatty liver disease (NAFLD) patients may cause mutation in DNA by deamination of cytosine to 5-hydroxyuracil or uracil. This study aimed to discover the effects of curcumin on NAFLD progress, DNA damage caused by oxidative stress, and promoter methylation of mismatch repair enzymes. Material and methods in this study, 54 NAFLD patients were randomly devided into two groups, according to a double blind parallel design either phytosomal curcumin (250 …
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